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์•ฝ์šฉ๋ฒ„์„ฏ ์ด์•ผ๊ธฐ(131): ๋ฟŒ๋ฆฌ๋ฒ„์„ฏ๋ฟŒ๋ฆฌ๋ฒ„์„ฏ์€ ์นจ์—ฝ์ˆ˜๋ฅผ ์ฃฝ์ด๋Š” ์น˜๋ช…์  ๊ธฐ์ƒ๊ท ์ด์ง€๋งŒ ์ด ๋ฒ„์„ฏ์˜ ์ถ”์ถœ๋ฌผ์€ ํŒจํ˜ˆ์ฆ์„ฑ ์‡ผํฌ๋ฅผ ๋ง‰์•„์ฃผ๋Š” ์‹ ์•ฝ ๊ฐœ๋ฐœ์— ์•„์ฃผ ์œ ์šฉํ•œ ๋ฒ„์„ฏ์ด๋‹ค.
์•ฝ์šฉ๋ฒ„์„ฏ ์ด์•ผ๊ธฐ(131): ๋ฟŒ๋ฆฌ๋ฒ„์„ฏ
 
๋ฟŒ๋ฆฌ๋ฒ„์„ฏ Heterobasidion annosum(Fr.) Bres. ์ฃฝ์€ ์นจ์—ฝ์ˆ˜ ๋ฟŒ๋ฆฌ ๊ทผ์ฒ˜์— ๋‹์€ ์งง์€ ๊ฐ“์„ ๋ณด์—ฌ์ค€๋‹ค. 
์ด ๊ธ€์— ๋‚˜์˜ค๋Š” ๋ชจ๋“  ์‚ฌ์ง„๋“ค์€ ๊ตฌ๊ธ€๊ฒ€์ƒ‰์—์„œ ์žฌ์‚ฌ์šฉ ๊ฐ€๋Šฅํ•œ ๊ฒƒ์„ ๋นŒ๋ ค ์˜จ ๊ฒƒ์ด๋‹ค.
์นจ์—ฝ์ˆ˜์˜ ๋ฟŒ๋ฆฌ๋‚˜ ๋ฐ‘๋™์„ ์ฉ๊ฒŒ ๋งŒ๋“œ๋Š” ์ด ๋ฒ„์„ฏ์€ ์นจ์—ฝ์ˆ˜๋ฆผ์˜ ํŒŒ๊ดด์ ์ธ ๊ธฐ์ƒ๊ท ์ด์ž ๋ถ€์ƒ๊ท ์ด๋‹ค. ๊ทธ ์ƒ๊ธด ๋ชจ์–‘ ๋˜ํ•œ ํŠน์ดํ•˜์—ฌ ๋ถˆ๊ทœ์น™ํ•˜๊ณ  ๊ณ ๋ฅด์ง€ ๋ชปํ•˜๋ฉฐ ๊ฑฐ์น ๋‹ค. ๋•Œ๋•Œ๋กœ ๊ฐ“์ด ์—†๊ธฐ๋„ ํ•˜์—ฌ ๋‹จ์ง€ ์ž์‹ค์ธต๋งŒ ๋ป—์–ด๊ฐ€๊ธฐ๋„ ํ•˜๊ณ  ๊ฐ“์ด ์žˆ์–ด๋„ ์ž์‹ค์ธต ์œ„๋กœ ๋‹จ์ง€ ์งง๊ฒŒ ๋‹์•„ ์žˆ์„ ๋ฟ์ด๋‹ค. ๊ฐ“์ด ์žˆ๋Š” ๊ฒฝ์šฐ ์„ ๋ฐ˜ ๋ชจ์–‘์ด๋‚˜ ์ฝฉํŒฅ ๋ชจ์–‘์ด๊ณ  ์•„์ฃผ ๋ฏธ์„ธํ•œ ์šฐ๋‹จ ๊ฐ™๊ฑฐ๋‚˜ ๋งค๋„๋Ÿฝ๋‹ค. ํฐ ํ…Œ๋‘๋ฆฌ๋ฅผ ๊ฐ€์ง„ ๊ฐˆ์ƒ‰์—์„œ ํ‘์ƒ‰์„ ๊ฐ€์ง€๊ณ  ์žˆ๊ณ  ํ”ํžˆ ์ž์‹ค์ฒด ๊ฐ€์žฅ์ž๋ฆฌ ๋ถ€์œ„์— ๋ถ‰์€ ํ…Œ ๋ชจ์–‘์„ ๊ฐ€์ง„ ๋ฌด๋Šฌ๊ฐ€ ์žˆ๋‹ค. ์‚ด(์กฐ์ง)์€ ํ—ˆ์—ฐ์ƒ‰์ด๊ณ  ์ž์‹ค์ธต์€ ํฌ๋ฆผ์ƒ‰์—์„œ ๋ˆ„๋ฅด์Šค๋ฆ„ํ•œ ์ƒ‰์ด๋‹ค. ์—ฐ์ค‘ ๋‚ด๋‚ด ํ™€๋กœ ๋‹๊ฑฐ๋‚˜ ๋ฌด๋ฆฌ์ง€์–ด ๋‹์•„๋‚˜ ์ผ๋…„์ƒ ๋˜๋Š” ๋‹ค๋…„์ƒ์ด๋ฉฐ ์ฃผ๋กœ ์นจ์—ฝ์ˆ˜ ๋ฟŒ๋ฆฌ๊ทผ์ฒ˜๋‚˜ ๋ฐ‘๋™์— ๋‹์•„ ๋ฐฑ์ƒ‰๋ถ€ํ›„๋ฅผ ์ผ์œผํ‚จ๋‹ค. ๋ถ๋ฏธ ์ „์—ญ์— ๋ถ„ํฌํ•œ๋‹ค. ๋ฌผ๋ก  ํ•œ๊ตญ์—์„œ๋„ ๋‹๋Š”๋‹ค.
 
๋ฟŒ๋ฆฌ๋ฒ„์„ฏ์˜ ์ž์‹ค์ธต ๋ชจ์Šต
๋ฟŒ๋ฆฌ๋ฒ„์„ฏ์˜ ์ „ํ†ต ์˜ํ•™์  ์‚ฌ์šฉ

๋ง๋ฆฐ ๋ฟŒ๋ฆฌ๋ฒ„์„ฏ์€ ๋œธ ์š”๋ฒ•(moxibustion)์˜ ํ•˜๋‚˜๋กœ ์‚ฌ์šฉ๋˜์—ˆ๋‹ค. ๋ฑ€์ด๋‚˜ ๋‹ค๋ฅธ ๋…์„ ๊ฐ€์ง„ ๋™๋ฌผ๋กœ ๋ง๋ฏธ์•”์•„ ์ƒ๊ธด ์ƒ์ฒ˜์— ์ถœํ˜ˆ์ด๋‚˜ ๊ฐ์—ผ์„ ๋ง‰๊ธฐ ์œ„ํ•ด ์ง€์ง€๊ฑฐ๋‚˜(์†Œ์ž‘ํ•˜๊ฑฐ๋‚˜) ๋œธ์„ ๋œจ๊ธฐ ์œ„ํ•˜์—ฌ ๋ฟŒ๋ฆฌ๋ฒ„์„ฏ์„ ์‚ฌ์šฉํ•œ ๊ฒƒ์ด๋‹ค. ๋˜ ๋ฏผ๊ฐ„ ์˜ํ•™์—์„œ ์•” ์น˜๋ฃŒ์ œ๋กœ ์‚ฌ์šฉํ•˜์˜€๋Š”๋ฐ, ํŠนํžˆ ์Šค์นธ๋””๋‚˜๋น„์•„ ๊ตญ๊ฐ€๋“ค์—์„œ ์•” ์น˜๋ฃŒ๋ฅผ ์œ„ํ•˜์—ฌ ๋ฟŒ๋ฆฌ๋ฒ„์„ฏ์„ ์‚ฌ์šฉํ•˜์˜€๋‹ค.

๋ฟŒ๋ฆฌ๋ฒ„์„ฏ์˜ ํ™”ํ•™์„ฑ๋ถ„

fomannosin, fommannoxin ์„ฑ๋ถ„์ด ๋“ค์–ด ์žˆ๊ณ , ๋‘ ์ข…๋ฅ˜์˜ ์‚ด๊ท  ์„ฑ๋ถ„์ด ๋“ค์–ด ์žˆ๋Š”๋ฐ ํ•˜๋‚˜๋Š” ์‹๋ฌผ๋…์†Œ (ๆค็‰ฉๆฏ’็ด  phytotoxic) ์„ฑ๋ถ„์ด๊ณ  ๋‹ค๋ฅธ ํ•˜๋‚˜๋Š” ํ—ฅ์‚ฌํŠธ๋ฆฌ์ธ (hexatryne) ์„ฑ๋ถ„์ด๋‹ค. ์ด ๋‘ ์„ฑ๋ถ„์— ๋Œ€ํ•ด์„œ๋Š” ๋” ์—ฐ๊ตฌ๊ฐ€ ํ•„์š”ํ•˜๋‹ค. ๋˜ ๋ฐฉ์•ˆ ์˜จ๋„์—์„œ ์‹ฌํ•˜๊ฒŒ ํญ๋ฐœํ•  ์ˆ˜ ์žˆ๋Š” ํŠธ๋ฆฌ์•„์„ธํ‹ธ๋ Œ (triacetylene)์ด ๋“ค์–ด ์žˆ๋‹ค.
 
์œ„ ๋ถ€๋ถ„์˜ ์‚ฌ์ง„์€ ๋ฟŒ๋ฆฌ๋ฒ„์„ฏ์˜ ํฐ ์ž์‹ค์ธต ๋ชจ์Šต์ด๊ณ , ์•„๋ž˜ ๋ถ€๋ถ„์€ ๊ฐ“์˜ ๋ชจ์Šต
๋ฟŒ๋ฆฌ๋ฒ„์„ฏ์˜ ์˜ํ•™์  ์‚ฌ์šฉ

ํ•ญ๊ท ์ž‘์šฉ: 1945๋…„ Robbins๋“ฑ์€ ๋ฟŒ๋ฆฌ๋ฒ„์„ฏ์˜ ํ™ฉ์ƒ‰ํฌ๋„์ƒ๊ตฌ๊ท ์— ๋Œ€ํ•œ ํ•ญ๊ท ์ž‘์šฉ์„ ๋ฐœ๊ฒฌํ•˜์˜€๊ณ , 1947๋…„ Herveys๋Š” ํ™ฉ์ƒ‰ํฌ๋„์ƒ๊ตฌ๊ท ์€ ๋ฌผ๋ก  ๋Œ€์žฅ๊ท ์— ๋Œ€ํ•œ ํ•ญ๊ท ์ž‘์šฉ๋„ ๋ฐœ๊ฒฌํ•˜์˜€๋‹ค.

2002๋…„ Koch ๋“ฑ์€ ๋ฟŒ๋ฆฌ๋ฒ„์„ฏ ์ž์‹ค์ฒด๊ฐ€ ์‹œํ—˜๊ด€๋‚ด(์ƒ์ฒด์™ธ) ์‹œํ—˜์—์„œ ๊ทธ๋žŒ์Œ์„ฑ๊ท ์„ ๋น„๋กฏํ•˜์—ฌ ๋ฉด์—ญ์„ธํฌ์˜ CD14 ์ˆ˜์šฉ์ฒด์— ์ด๋ฅด๊ธฐ๊นŒ์ง€ ์ง€์งˆ๋‹ค๋‹น๋ฅ˜(่„‚่ณชๅคš็ณ–้กž)(lipopolysaccharide=LPS)์™€์˜ ๊ฒฐํ•ฉ์„ ๋ง‰์•„์ค€๋‹ค๋Š” ๊ฒƒ์„ ๋ฐœ๊ฒฌํ•˜์˜€๋‹ค.  CD14์ˆ˜์šฉ์ฒด๋ž€ "cluster of differentiation 14"์˜ ์•ฝ์ž๋กœ ์ธ๊ฐ„ ์œ ์ „์ž์˜ ํ•˜๋‚˜์ด๋‹ค. ์ด ์œ ์ „์ž๋กœ ๋ถ€ํ˜ธํ™”ํ•œ ๋‹จ๋ฐฑ์งˆ์€ ์„ ์ฒœ ๋ฉด์—ญ์ฒด๊ณ„ ์•ˆ์— ์žˆ๋Š” ํ•œ ์„ฑ๋ถ„์ด๋‹ค. ์ด ์ง€์งˆ๋‹ค๋‹น๋ฅ˜์™€์˜ ๊ฒฐํ•ฉ์€ ์ผ๋ จ์˜ ์—ผ์ฆ๋งค๊ฐœ์ฒด์™€ ํ™œ์„ฑ ์‚ฐ์†Œ์ข…(็จฎ) ์ง€๋„๋ฅผ ๋ฐฉ์ถœํ•˜๋Š” ํŒจํ˜ˆ์ฆ์„ฑ(ๆ•—่ก€็—‡ๆ€ง) ์‡ผํฌ ์ฆํ›„๊ตฐ์˜ ํ•œ ๋ถ€๋ถ„์œผ๋กœ ๊ฒฝ์šฐ์— ๋”ฐ๋ผ ์‚ฌ๋ง์— ์ด๋ฅด๊ฒŒ ํ•œ๋‹ค. ํŒจํ˜ˆ์ฆ์„ฑ์‡ผํฌ(ๆ•—่ก€็—‡ๆ€ง~)๋ž€ ์‹ฌํ•œ ๊ฐ์—ผ์ฆ์ด ์žˆ์„ ๋•Œ์— ์ผ์–ด๋‚˜๋Š” ์‡ผํฌ๋กœ์„œ, ํŠนํžˆ ๊ทธ๋žŒ์Œ์„ฑ์„ธ๊ท ์— ์˜ํ•œ ํŒจํ˜ˆ์ฆ ๋ฐ ๋‚ด๋…์†Œ์˜ ๋ฐฉ์ถœ(endotoxin shock)์—์„œ ์˜ค๋Š” ์‡ผํฌ์ด๋‹ค.

๋ฟŒ๋ฆฌ๋ฒ„์„ฏ ์™ธ์—๋„ ํŒจํ˜ˆ์ฆ์„ฑ ์‡ผํฌ๋ฅผ ์ผ์œผํ‚ค๋Š” ์ง€์งˆ๋‹ค๋‹น๋ฅ˜์™€ ์ˆ˜์šฉ์ฒด์˜ ๊ฒฐํ•ฉ์„ ๋ง‰์•„์ฃผ๋Š” ๋ฒ„์„ฏ๋“ค์€ ๊ฒ€์ •๋Œ€๋ฐค๊ฐ€์ฃฝ๋ฒ„์„ฏ(Polyporus badius [Gray] Schwein.), ์ƒˆํ„ธ์ –๋ฒ„์„ฏ (Lacatrius vellereus [Fr.] Fr.), ๊ตฌ๋ฆ„์†กํŽธ๋ฒ„์„ฏ(Trametes versicolor[L.] Lloyd), ๊ทธ๋ฆฌ๊ณ  ์ž์ž‘๋‚˜๋ฌด๋ฒ„์„ฏ(Piptoporus betulinus[Bull.] P. Karst.) ๋“ฑ์ด ์žˆ๋‹ค.
 
์นจ์—ฝ์ˆ˜ ๋ฟŒ๋ฆฌ ๊ทผ์ฒ˜์— ๋‹๋Š” ๋ฟŒ๋ฆฌ๋ฒ„์„ฏ์€ ๊ฐ“์ด ์žˆ์–ด๋„ ์•„์ฃผ ์งง๋‹ค.
๋ฟŒ๋ฆฌ๋ฒ„์„ฏ์€ ์•„ํŽธ๊ณผ ํก์‚ฌํ•œ ์ž‘์šฉ์„ ๊ฐ€์ง„ ํ†ต์ฆ์น˜๋ฃŒ๋ฅผ ์œ„ํ•œ ์‹ ์•ฝ๊ฐœ๋ฐœ์— ์œ ์šฉํ•œ ๋ฒ„์„ฏ์ผ ์ˆ˜ ์žˆ๋‹ค๊ณ  ํ•œ๋‹ค. ๋˜ ๋ฟŒ๋ฆฌ๋ฒ„์„ฏ์€ ๊ทธ ์‚ฐํ™”ํšจ์†Œ ๋•Œ๋ฌธ์— ํŽ˜๋†€(๋ฌผ์— ๋…น์—ฌ ์†Œ๋…์ œใƒป๋ฐฉ๋ถ€์ œ ๋“ฑ์œผ๋กœ ์“ฐ๋Š” ์œ ๋…์„ฑ ํ™”ํ•™ ๋ฌผ์งˆ)์— ๋Œ€ํ•˜์—ฌ ์ด์ƒ(๋น„์ •์ƒ์ ) ์ƒ‰์†Œ๋ฅผ ๋งŒ๋“ค์–ด ๋‚ธ๋‹ค. ๊ทธ๋ฆฌ๊ณ  ๋ฟŒ๋ฆฌ๋ฒ„์„ฏ์€ ๋ชฉ์งˆ์†Œ ๋ถ„ํ•ด์— ํฐ ์—ญํ™œ์„ ๋‹ด๋‹นํ•˜๋Š” ๋ฒ„์„ฏ์ผ ๊ฐ€๋Šฅ์„ฑ์ด ์žˆ๋‹ค.

๋ฟŒ๋ฆฌ๋ฒ„์„ฏ์€ ํŠนํžˆ ์นจ์—ฝ์ˆ˜๋ฆผ์— ํฐ ํํ•ด๋ฅผ ์ฃผ๊ธฐ ๋•Œ๋ฌธ์— ํ˜„์žฌ ์„ธ๊ณ„์ ์œผ๋กœ ๋ฟŒ๋ฆฌ๋ฒ„์„ฏ์˜ ๊ท ์‚ฌ ์„ฑ์žฅ์„ ์–ต์ œํ•  ์ˆ˜ ์žˆ๋Š” ๋‹ค๋ฅธ ์‹๋ฌผ์ด๋‚˜ ๋ฒ„์„ฏ์ด ์žˆ๋Š”์ง€ ์ฐพ๊ณ  ์žˆ๋‹ค๊ณ  ํ•œ๋‹ค. ์ฐธ๊ณ ์‚ผ์•„ ์˜๊ตญ์—์„œ๋Š” 90%์˜ ์นจ์—ฝ์ˆ˜๊ฐ€ ๋ฟŒ๋ฆฌ๋ฒ„์„ฏ ๋•Œ๋ฌธ์— ์ฉ์–ด๊ฐ€๊ณ  ์žˆ๋‹ค ํ•˜๋‹ˆ ์ด๋ฅผ ๋ง‰์•„๋‚ผ ๋ฐฉ๋„๋ฅผ ์ฐพ๋Š” ๊ฒƒ์€ ๋‹น์—ฐํ•˜๋‹ค. @

์ฐธ๊ณ ๋ฌธํ—Œ:

Robert Rogers, The Fungal Pharmacy: The Complete Guide to Medicinal Mushrooms and Lichens of North America, Berkeley, Calif.: North Atlantic Press, 2011, p. 215-216.

ํŒจํ˜ˆ์ฆ์„ฑ ์‡ผํฌ๋ฅผ ์ผ์œผํ‚ค๋Š” ์›์ธ๊ณผ ๊ทธ๊ฒƒ์„ ๋ง‰์•„์ฃผ๋Š” ๋ฟŒ๋ฆฌ๋ฒ„์„ฏ์˜ ์ถ”์ถœ๋ฌผ์— ๋Œ€ํ•œ ์ •๋ณด๋Š” ์ธํ„ฐ๋„ท ๊ฒ€์ƒ‰์—์„œ Ulrike Lindequist, Timo H. J. Niedermeyer, and Wolf-Dieter Jülich, The Pharmacological Potential of Mushrooms, Evidence- Based Complementary Alternative Medcine, 2005 Sep; 2(3): 285–299. PMC1193547 ๋ผ๋Š” ๋…ผ๋ฌธ ๊ฐ€์šด๋ฐ “Influence on Lipopolysaccharide Binding”๋ผ๋Š” ๋ถ€๋ถ„์„ ๋ณผ ๊ฒƒ.

Septic shock is a complex syndrome mediated by binding of lipopolysaccharide (LPS) from gram-negative bacteria to CD14 receptor on immune cells and the following release of a cascade of inflammatory mediators and reactive oxygen species. Because of the large number of patients with septic shock a great deal of effort is necessary to develop new therapeutic possibilities. Extracts of the fruiting bodies of ๊ฒ€์ •๋Œ€๋ฐค๊ฐ€์ฃฝ๋ฒ„์„ฏPolyporus badius (Gray) Schwein., ์ƒˆํ„ธ์ –๋ฒ„์„ฏ Lacatrius vellereus (Fr.) Fr., ๋ฟŒ๋ฆฌ๋ฒ„์„ฏHeterobasidion annosum (Fr.) Bres., ๊ตฌ๋ฆ„์†กํŽธ๋ฒ„์„ฏ Trametes versicolor and ์ž์ž‘๋‚˜๋ฌด๋ฒ„์„ฏPolyporus betulinus inhibit in vitro binding of LPS to the receptor (104) and could therefore contain lead structures for drugs against LPS-mediated septic shock.

์ตœ์ข…์ˆ˜(์•ผ์ƒ๋ฒ„์„ฏ์• ํ˜ธ๊ฐ€) ๊ธฐ์ž, ๋‹ค๋ฅธ๊ธฐ์‚ฌ๋ณด๊ธฐ๊ธฐ์‚ฌ๋“ฑ๋ก์ผ์‹œ : 2018.02.20 12:51

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